Quartet for the End of Time

A winner of the John S. Knight Assignment Sequence Prize, this sequence originates from Music 111, Sound, Sense, and Ideas: Famous First Performances. The sequence consists of four units, each of which focuses on a separate composer (Berlioz, Beethoven, Dvorak, and Stravinsky). A fifth unit prepares students to write a review of a concert they attend. Preparatory writing includes personal writing as well as study questions; essay assignments draw on varying genre and rhetorical situations. The sequence aims to turn students into active listeners who can employ musicological terminology while considering the social environments that shaped composers and their audiences. To this end, writing assignments require participation in the "narrative" mode of discourse that musicologists use to explain historical events and works. 12 page pd

Assessing the style of advance and retreat of the Des Moines Lobe using LiDAR topographic data

Successive advances of the late-Wisconsinan Des Moines Lobe to form three major end moraines in Iowa--sequentially the Bemis, Altamont, and Algona moraines--are thought to be the result of the lobe surging out of balance with a warming climate. Various styles of hummocky topography, collectively sometimes called stagnation moraine, are interpreted to be the result of widespread stagnation and down-wasting of ice following surges. Alternatively, end moraines could be recessional--a result of incremental back-wasting of the glacier margin and unrelated to surging. To study the retreat style of the Des Moines Lobe, high resolution LiDAR data were used to re-evaluate the subtle landscape of the lobe\u27s footprint in Iowa. Results indicate that ~90% of the lobe\u27s area, excluding major Holocene stream drainages, consists of stagnation features. Some landforms are more prevalent than mapped previously, including eskers and features interpreted to be subdued ice-walled lake plains. Importantly, subglacially formed minor moraines (a.k.a. washboard moraines), which resulted from sediment filling of transverse crevasses, cover ~60% of the lobe\u27s area with stagnation landforms. Also, ~25 previously unmapped end moraine ridges have been identified. Transverse crevasse-fill ridges in the forefields of modern glaciers form due to longitudinal ice extension associated with surging and are not found in the forefields of non-surge-type glaciers, so minor moraines are good evidence of Des Moines Lobe surges. Most end moraines have minor moraine sets associated with them, consistent with a surge-like advances, and many areas have multiple sets of minor moraines indicating a surge history more complicated than one advance for each of the three major end moraines. Therefore, asserting stagnation and down-wasting after three surge-like advances provides an incomplete characterization of the Des Moines Lobe\u27s advance and retreat. The surge-type Bering Glacier in Alaska is a good but imperfect modern analog for the lobe

In situ apparatus for the study of clathrate hydrates relevant to solar system bodies using synchrotron X-ray diffraction and Raman spectroscopy

Clathrate hydrates are believed to play a significant role in various solar system environments, e.g. comets, and the surfaces and interiors of icy satellites, however the structural factors governing their formation and dissociation are poorly understood. We demonstrate the use of a high pressure gas cell, combined with variable temperature cooling and time-resolved data collection, to the in situ study of clathrate hydrates under conditions relevant to solar system environments. Clathrates formed and processed within the cell are monitored in situ using synchrotron X-ray powder diffraction and Raman spectroscopy. X-ray diffraction allows the formation of clathrate hydrates to be observed as CO2 gas is applied to ice formed within the cell. Complete conversion is obtained by annealing at temperatures just below the ice melting point. A subsequent rise in the quantity of clathrate is observed as the cell is thermally cycled. Four regions between 100-5000cm-1 are present in the Raman spectra that carry features characteristic of both ice and clathrate formation. This novel experimental arrangement is well suited to studying clathrate hydrates over a range of temperature (80-500K) and pressure (1-100bar) conditions and can be used with a variety of different gases and starting aqueous compositions. We propose the increase in clathrate formation observed during thermal cycling may be due to the formation of a quasi liquid-like phase that forms at temperatures below the ice melting point, but which allows easier formation of new clathrate cages, or the retention and delocalisation of previously formed clathrate structures, possibly as amorphous clathrate. The structural similarities between hexagonal ice, the quasi liquid-like phase, and crystalline CO2 hydrate mean that differences in the Raman spectrum are subtle; however, all features out to 5000cm-1 are diagnostic of clathrate structure.Comment: Astronomy & Astrophysics, in press. 6 page

A systematic review of reviews of interventions to promote mental health and prevent mental health problems in children and young people

Background: There is a growing policy imperative to promote positive mental health as well as preventing the development of mental health problems in children. This paper summarises the results of published systematic reviews evaluating interventions to promote mental health and prevent mental illness in children. Method: A search was undertaken of ten electronic databases using a combination of medical subject headings (MeSH) and free text searches. Systematic reviews covering mental health promotion or mental illness prevention interventions aimed at infants, children or young people up to age 19 were included. Reviews of drug and alcohol prevention programmes or programmes to prevent childhood abuse and neglect were excluded because these have been the subject of recent good quality reviews of reviews. Critical appraisal of all studies was undertaken using a standardised appraisal tool for systematic reviews. Where possible effect sizes and 95% confidence intervals are reported. A narrative summary has been provided. Results: A total of 27 systematic reviews were included and grouped pragmatically under the following headings: parenting interventions; programmes for the prevention of anxiety and depression, programmes to promote self esteem, violence and aggression prevention programmes, school-based programmes, and general reviews. Included studies targeted a range of risk and protective factors, and a range of populations (including both parents and children). While, many lacked methodological rigour, overall, the evidence is strongly suggestive of the effectiveness of a range of interventions in promoting positive mental well-being, and reducing key risk factors for mental illness in children. Conclusion: A variety of programmes have been shown to be effective in promoting children’s mental health, albeit with modest effect sizes. Based on this evidence, arguments are advanced for the preferential provision of early preventive programmes

Galcanezumab in episodic migraine: subgroup analyses of efficacy by high versus low frequency of migraine headaches in phase 3 studies (EVOLVE-1 & EVOLVE-2).

BACKGROUND: Patients with high-frequency episodic migraine (HFEM) have a greater disease burden than those with low-frequency episodic migraine (LFEM). Acute treatment overuse increases the risk of migraine chronification in patients with HFEM. Galcanezumab, a humanized monoclonal antibody binding calcitonin gene-related peptide (CGRP), is effective for migraine prevention with a favorable safety profile. Here, we investigate whether there are differences in galcanezumab efficacy in patients with LFEM or with HFEM. METHODS: Data were pooled from two double-blind, placebo-controlled phase 3 trials; EVOLVE-1 and EVOLVE-2. Patients were 18-65 years old, experienced 4-14 monthly migraine headache days (MHDs) for ≥1 year prior, with onset at \u3c 50 years of age. Migraine headaches were tracked via electronic patient-reported outcome system and randomization was stratified by low (LFEM; 4-7 monthly MHDs) or high (HFEM; 8-14 monthly MHDs) frequency. Subgroup analysis compared the HFEM and LFEM subgroups with a linear or generalized linear mixed model repeated measures approach. RESULTS: The intent-to-treat patients (N = 1773) had a mean age of 41.3 years, were mostly white (75%), female (85%), and 66% of patients had HFEM. In both the LFEM and HFEM subgroups, the overall (Months 1-6) and monthly changes from baseline in monthly MHDs and monthly MHDs with acute medication use compared with placebo were statistically significantly reduced for galcanezumab 120-mg and 240-mg. Galcanezumab (120-mg and 240-mg) significantly decreased the overall and monthly MHDs with nausea and/or vomiting, and with photophobia and phonophobia versus placebo in patients with LFEM or HFEM. In both subgroups, the mean overall (Months 1-6) and monthly percentages of patients with ≥50%, ≥75%, and 100% reduction in monthly MHDs from baseline were statistically significantly greater in patients receiving either dose of galcanezumab versus placebo. Galcanezumab (120-mg and 240-mg) significantly improved the Migraine-Specific Quality of Life Questionnaire role function-restrictive domain score as well as the Migraine Disability Assessment total score versus placebo for patients with LFEM or HFEM. There were no significant subgroup-by-treatment interactions. CONCLUSIONS: Galcanezumab was as effective in patients with HFEM as in those with LFEM. Associated symptoms, quality of life, and disability were similarly improved in patients with HFEM or LFEM. TRIAL REGISTRATION: NCT02614183 , NCT02614196

Utilising 3D printing techniques when providing unique assistive devices : a case report

Background – The evolution of 3D printing into prosthetics has opened conversations about the availability, and cost of prostheses. This report will discuss how a Prosthetic team incorporated additive manufacture techniques into the treatment of a patient with a amputation to create and test a unique assistive device which he could use to hold his French horn. Case Description and Methods –Using a process of shape capture, photogrammetry, CAD and Finite Element Analysis (FEA), a suitable assistive device was designed and tested. The design was fabricated using 3D printing. Patient satisfaction was measured using a Pugh’s Matrix, and a cost comparison was made between the process used and traditional manufacturing. Findings – Patient satisfaction was high. The 3D printed devices were 56% cheaper to fabricate than a similar laminated device. Outcome and Conclusion – CAD and 3D printing proved an effective method for designing, testing and fabricating a unique assistive device